The Glutamate Hypothesis of Schizophrenia – Review and Updates
Lawrence S Kegeles, MD, PhD
Schizophrenia and other psychotic disorders remain the bread and butter of psychiatry. Decades of research have brought advances in combating (but not conquering) issues such as cognitive dysfunction, diminished social functioning, high suicide risk, shortened lifespan, metabolic syndrome, drug hesitancy, and more. The Glutamate Hypothesis has long been part of this pursuit of superior remedies and of uncovering the brain bases of schizophrenia and has led to an increasingly sophisticated picture of its synaptic chemistry. The in vivo measurement of glutamate with magnetic resonance spectroscopy (MRS) has played a part.
Our speaker, Dr. Lawrence Kegeles, physicist, psychiatrist, and top-flight MR spectroscopist, has measured MRS glutamate and GABA in schizophrenia, OCD, major depression and other conditions. And he has synthesized his results into a coherent model of excitation/inhibition in the brain. Come learn the ins-and-outs of the Glutamate Hypothesis and its latest developments from a bona fide authority.
